IPF
Immature Platelet Fraction
ipf levels aka the cell count levels are tested at Jaguthi using XN550
Sometimes small things make a BIG difference
What is Immature Platelet Fraction counting?
IPF levels rise as bone marrow produces more platelets. Measuring IPF therefore reflects bone
marrow platelet production from a peripheral blood sample similar to how a reticulocyte count
could provide a measure of red cell production.
The immature platelet fraction is a modern parameter that measures young and more reactive
platelets in peripheral blood. Haematology analysers equipped with PLT-F offer two diagnostic
parameters; the absolute immature platelet count (IPF#) and the fraction of immature platelets
related to mature platelets (IPF%).
Why count immature platelets?
IPF has a high clinical utility in the laboratory diagnosis and treatment of thrombocytopenia since
raised IPF levels are related to increased peripheral platelet destruction. It is particularly useful for
supporting the diagnosis of autoimmune thrombocytopenic purpura, thrombotic
thrombocytopenic purpura and for distinguishing these from bone marrow suppression or failure.
In the latter, the IPF value would be low.
The IPF can be a sensitive measure for evaluating thrombopoietic recovery during aplastic
chemotherapy and is suggested to be useful for monitoring patients after chemotherapy and
haematopoietic stem cell transplantation.
Causes
Increased consumption/destruction ( ITP,TTP,DIC)-High IPF.
Decreased production (Marrow failure) –Low IPF.
IPF test predicts the timing of platelet recovery in Dengue
Thrombocytopenia
Immature Platelet Fraction – IPF
Reference Range – 1.6-6.7% ( Mean 4%)
Very high values for IPF% ( >10%)
(Only suspected ITP without significantly elevated IPF% shall undergo bone marrow examination).
TTP, DIC -high values of IPF% within the respective clinical setting will support or suggest the
diagnosis of DIC.
(TTP – Elevated LDH, Schistocytes in smear )
(DIC – Prolonged PT, aPTT and FDP Positive.)
We use Sysmex XN550 to determine cell count at a very high accuracy and there by improve the test results like never before in Rajahmundry.
Marrow Failure
IPF% will be on the low side. However, as soon as the bone marrow recovers, IPF%
will rise.
Dengue
The Immature Platelet Fraction (IPF) is a predictive marker for platelet recovery. The platelet
count tends to recover within 24 to 48 hours in Dengue patient if the value of Immature Platelet
Fraction (IPF) is more than 8%.
Summary:
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To know more about Immature Platelet Fraction and related test details and its equipment at jagruthi Rajahmundry plase visit Hematology